From pharmaceutical standardizing to clinical research: 20 years of experience with fifty-millesimal potencies / Da padronização farmacêutica à pesquisa clínica: 20 anos de experiência com potências cinquenta-milesimais

Background: 20 years ago we began to standardize the procedures of preparation and use of fifty-millesimal dilutions (LM or Q) according to indications in the 6th edition of Hahnemann’s Organon. Aim: to describe the main stages in standardization as well as our teaching and research experience on Organon 6th edition. Results: with the use of standardized LM dilutions we observed a lower incidence of homeopathic aggravation than with our earlier experience with non standardized preparations. Organon.modus, a clinical-pharmaceutical protocol derived from the standardization was adequate for the teaching of homeopathy at Faculty of Medicine of Jundiai (São Paulo), the first Brazilian medical school with a graduate course on homeopathy. A randomized double-blind trial comparing individualized homeopathic medicines prescribed in LM dilutions and fluoxetine showed the former not be inferior to the latter in the treatment of moderate-to-severe depression. Conclusion: protocol Organon.modus showed to be adequate to graduate-level teaching of homeopathy and efficient in a controlled clinical trials, favoring its use as common denominator between the art of healing and medical science.(AU)

Introdução: Iniciamos há 20 anos, uma padronização dos procedimentos para o preparo e uso das potências cinquenta-milesimais (LM ou Q) de acordo com a 6ª edição do Organon. Objetivo: Relatar as principais etapas dessa padronização e nossa experiência com o ensino e a pesquisa usando os princípios essenciais da a 6ª edição do Organon. Resultados: Observamos uma menor incidência de agravações homeopáticas com o uso de medicamentos padronizados, em relação à nossa experiência anterior com potências LM não padronizadas. O protocolo clínico-farmacêutico, que aqui denominamos Organon.modus, mostrou-se adequado ao ensino da Homeopatia na Faculdade de Medicina de Jundiaí, primeira escola de Medicina no Brasil a oferecer uma especialização em Homeopatia para médicos. Potências LM individualizadas não foram inferiores ao antidepressivo fluoxetina no tratamento de pacientes com depressão moderada a grave em um estudo randomizado e duplo-cego. Conclusão: O protocolo Organon.modus mostrou-se adequado ao ensino acadêmico da Homeopatia e eficaz em um estudo clínico controlado, resultados que favorecem seu uso como denominador comum entre a arte de curar e a ciência médica.(AU)

From pharmaceutical standardizing to clinical research: 20 years of experience with fifty-millesimal potencies

Background: 20 years ago we began to standardize the procedures of preparation and use of fifty-millesimal dilutions (LM or Q) according to indications in the 6th edition of Hahnemann?s Organon. Aim: to describe the main stages in standardization as well as our teaching and research experience on Organon 6th edition. Results: with the use of standardized LM dilutions we observed a lower incidence of homeopathic aggravation than with our earlier experience with non standardized preparations. Organon.modus, a clinical-pharmaceutical protocol derived from the standardization was adequate for the teaching of homeopathy at Faculty of Medicine of Jundiai (São Paulo), the first Brazilian medical school with a graduate course on homeopathy. A randomized double-blind trial comparing individualized homeopathic medicines prescribed in LM dilutions and fluoxetine showed the former not be inferior to the latter in the treatment of moderate-to-severe depression. Conclusion: protocol Organon.modus showed to be adequate to graduate-level teaching of homeopathy and efficient in a controlled clinical trials, favoring its use as common denominator between the art of healing and medical science.